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Ein `!Uncoupling Protein`! (‚Entkopplungsprotein‘) ist ein `F33f`_`[mitochondriales`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Mitochondrium]`_`f `F33f`_`[Membranprotein`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Membranprotein]`_`f, das `F33f`_`[Protonen`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Proton]`_`f ohne `F33f`_`[chemiosmotische Kopplung`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Chemiosmotische_Kopplung]`_`f durch die mitochondriale Membran lässt und somit die `F33f`_`[Atmungskette`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Atmungskette]`_`f entkoppelt.`:cite-ref-pmid16179945-1-0[`F5bf`_`[1`#cite-note-pmid16179945-1]`_`f]

>>Contents

• `F0af`_`[Eigenschaften`#eigenschaften]`_`f

• `F0af`_`[Weblinks`#weblinks]`_`f

• `F0af`_`[Einzelnachweise`#einzelnachweise]`_`f

-─

>>Eigenschaften

In Säugetieren gibt es fünf Typen:

• `F33f`_`[UCP1`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=UCP1]`_`f (synonym `F33f`_`[Thermogenin`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Thermogenin]`_`f)`:cite-ref-2[`F5bf`_`[2`#cite-note-2]`_`f]

• UCP2`:cite-ref-3[`F5bf`_`[3`#cite-note-3]`_`f]

• UCP3`:cite-ref-4[`F5bf`_`[4`#cite-note-4]`_`f]

• SLC25A27 (synonym `*UCP4`*)`:cite-ref-5[`F5bf`_`[5`#cite-note-5]`_`f]

• SLC25A14 (synonym `*UCP5`*)`:cite-ref-6[`F5bf`_`[6`#cite-note-6]`_`f]

`*Uncoupling Proteins`* dienen der `F33f`_`[Thermogenese`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Thermogenese]`_`f, da die Protonen an `F33f`_`[Fettsäuren`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Fettsäure]`_`f gebunden aus dem Inneren des Mitochondriums an der `F33f`_`[membranständigen ATPase`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Membranständige_ATPase]`_`f vorbei ins `F33f`_`[Zytoplasma`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Zytoplasma]`_`f geschleust werden, um `F33f`_`[Neutralisationswärme`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Neutralisationswärme]`_`f zu erzeugen.`:cite-ref-7[`F5bf`_`[7`#cite-note-7]`_`f] Chemische Entkoppler der Atmungskette sind z. B. `F33f`_`[2,4-Dinitrophenol`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=2,4-Dinitrophenol]`_`f,`:cite-ref-8[`F5bf`_`[8`#cite-note-8]`_`f] Carbonylcyanid m-chlorphenyl-Hydrazon (CCCP),`:cite-ref-9[`F5bf`_`[9`#cite-note-9]`_`f] `F33f`_`[Malachitgrün`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Malachitgrün]`_`f,`:cite-ref-10[`F5bf`_`[10`#cite-note-10]`_`f] `F33f`_`[Salicylsäure`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Salicylsäure]`_`f und teilweise auch `F33f`_`[Essigsäure`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Essigsäure]`_`f. UCP werden durch `F33f`_`[Schilddrüsenhormone`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Schilddrüsenhormon]`_`f, `F33f`_`[Adrenalin`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Adrenalin]`_`f, `F33f`_`[Noradrenalin`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Noradrenalin]`_`f und `F33f`_`[Leptin`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Leptin]`_`f `F33f`_`[induziert`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Induktion_(Genetik)]`_`f.`:cite-ref-11[`F5bf`_`[11`#cite-note-11]`_`f]

>>Weblinks

• `F33f`_`[MeSH`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Medical_Subject_Headings]`_`f `*Uncoupling Protein`*

>>Einzelnachweise

`:cite-note-pmid16179945-1`!1.`! `F0af`_`[↑`#cite-ref-pmid16179945-1-0]`_`f Nedergaard J, Ricquier D, Kozak LP: Uncoupling proteins: current status and therapeutic prospects. In: EMBO Rep. 6. Jahrgang, Nr. 10, 2005, S. 917–21, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1038/sj.embor.7400532, PMID 16179945, PMC 1369193 (freier Volltext).

`:cite-note-2`!2.`! `F0af`_`[↑`#cite-ref-2]`_`f R. K. Porter: `*Uncoupling protein 1: a short-circuit in the chemiosmotic process.`* In: `*Journal of bioenergetics and biomembranes.`* Band 40, Nummer 5, Oktober 2008, S. 457–461, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1007/s10863-008-9172-8. PMID 18958609.

`:cite-note-3`!3.`! `F0af`_`[↑`#cite-ref-3]`_`f S. Diano, T. L. Horvath: `*Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism.`* In: `*`F33f`_`[Trends in Molecular Medicine`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Trends_in_Molecular_Medicine]`_`f.`* Band 18, Nummer 1, Januar 2012, S. 52–58, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1016/j.molmed.2011.08.003. PMID 21917523.

`:cite-note-4`!4.`! `F0af`_`[↑`#cite-ref-4]`_`f M. Nabben, J. Hoeks: `*Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism.`* In: `*Physiology & behavior.`* Band 94, Nummer 2, Mai 2008, S. 259–269, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1016/j.physbeh.2007.11.039. PMID 18191161.

`:cite-note-5`!5.`! `F0af`_`[↑`#cite-ref-5]`_`f P. W. Ho, J. W. Ho, H. M. Tse, D. H. So, D. C. Yiu, H. F. Liu, K. H. Chan, M. H. Kung, D. B. Ramsden, S. L. Ho: `*Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.`* In: `*`F33f`_`[PLOS ONE`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=PLOS_ONE]`_`f.`* Band 7, Nummer 2, 2012, S. e32810, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1371/journal.pone.0032810. PMID 22427795. PMC 3303587 (freier Volltext).

`:cite-note-6`!6.`! `F0af`_`[↑`#cite-ref-6]`_`f P. W. Ho, A. C. Chu, K. H. Kwok, M. H. Kung, D. B. Ramsden, S. L. Ho: `*Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity.`* In: `*Journal of neuroscience research.`* Band 84, Nummer 6, 2006, S. 1358–1366, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1002/jnr.21034. PMID 16941493.

`:cite-note-7`!7.`! `F0af`_`[↑`#cite-ref-7]`_`f P. Jezek, M. Jab?rek, K. D. Garlid: `*Channel character of uncoupling protein-mediated transport.`* In: `*FEBS letters.`* Band 584, Nummer 10, 2010, S. 2135–2141, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1016/j.febslet.2010.02.068. PMID 20206627. PMC 3617986 (freier Volltext).

`:cite-note-8`!8.`! `F0af`_`[↑`#cite-ref-8]`_`f Y. Jin, M. L. McEwen, S. A. Nottingham, W. F. Maragos, N. B. Dragicevic, P. G. Sullivan, J. E. Springer: `*The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.`* In: `*Journal of neurotrauma.`* Band 21, Nummer 10, Oktober 2004, S. 1396–1404, PMID 15672630.

`:cite-note-9`!9.`! `F0af`_`[↑`#cite-ref-9]`_`f K. Kaila, K. Mattsson, J. Voipio: `*Fall in intracellular pH and increase in resting tension induced by a mitochondrial uncoupling agent in crayfish muscle.`* In: `*The Journal of physiology.`* Band 408, Januar 1989, S. 271–293, PMID 2778730. PMC 1190403 (freier Volltext).

`:cite-note-10`!10.`! `F0af`_`[↑`#cite-ref-10]`_`f G. Werth, A. Boiteux: `*Toxicity of triphenylmethane dyes. Malachite green as an uncoupling agent of oxidative phosphorylation in vivo and in vitro.`* In: `*Archiv für Toxikologie.`* Band 23, Nummer 2, 1968, S. 82–103, PMID 4299566.

`:cite-note-11`!11.`! `F0af`_`[↑`#cite-ref-11]`_`f Gong DW, He Y, Karas M, Reitman M: Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin. In: J Biol Chem. 272. Jahrgang, Nr. 39, 1997, S. 24129–24132, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1074/jbc.272.39.24129 (jbc.org).

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